Symbol
Name
ID

Cdkn1b
cyclin dependent kinase inhibitor 1B
MGI:104565

Phenotype annotations related to endocrine/exocrine glands

Darker colors indicate more annotations

Human Phenotypes	Elevated circulating growth hormone concentration	Pituitary adenoma	Parathyroid adenoma	Hyperparathyroidism	Primary hyperparathyroidism	Hashimoto thyroiditis	Hypothyroidism	Carcinoid tumor	Pancreatic endocrine tumor
Disease(s) Associated with CDKN1B
multiple endocrine neoplasia type 4

Mouse Phenotypes

adrenal medulla hyperplasia

enlarged adrenal glands

increased pituitary gland weight

enlarged pituitary gland

pituitary gland hyperplasia

abnormal pituitary intermediate lobe morphology

pituitary intermediate lobe hyperplasia

abnormal thymus morphology

increased thymus weight

enlarged thymus

thymus hyperplasia

increased thymocyte number

abnormal prostate gland dorsolateral lobe morphology

enlarged prostate gland

abnormal corpus luteum morphology

absent corpus luteum

abnormal ovarian follicle morphology

abnormal granulosa cell morphology

absent tertiary ovarian follicles

impaired ovarian folliculogenesis

enlarged ovary

enlarged testis

testicular hyperplasia

increased ovary tumor incidence

increased pituitary gland tumor incidence

increased pituitary adenoma incidence

abnormal prostate gland physiology

Availability

Mouse Genotype

Cdkn1b^tm1Ako/Cdkn1b^tm1Ako

Cdkn1b^tm1Kin/Cdkn1b^tm1Kin

Cdkn1b^tm1Mlf/Cdkn1b^tm1Mlf

Cdkn1b^tm3Mlf/Cdkn1b^tm3Mlf

Cdkn1b^tm2Mlf/Cdkn1b^tm2Mlf
Tg(Pomc1-cre)1Mlf/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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